Severe hypertension (systolic ≥ 160 mmHg or diastolic ≥ 100 mmHg).Hypertension resistant to medical treatment.Up to 38% have normal potassium levels, but most patients do have hypokalemia, usually associated with these symptoms:Ĭonn’s disease should be suspected in patients with the following problems: It is important to differentiate between the two because APA (but not IHA) is treated surgically.Ĭonn’s disease usually affects women and men equally, typically between age 30 and 60. APA results from excess secretion of aldosterone from 1 adrenal gland (unilateral), whereas IHA results when both adrenal glands oversecrete aldosterone (bilateral). Of all patients with Conn’s disease, 95% have either an aldosterone-producing adenoma (a benign tumor) (APA) or bilateral adrenal hyperplasia (an abnormal increase in the number of normal cells), which is also known as idiopathic (cause unknown) hyperaldosteronism (IHA). Of all patients with hypertension, 5% to 14% have undiagnosed Conn’s disease. Patients with Conn’s disease usually have hypertension (high blood pressure) and commonly hypokalemia (low blood potassium). Conn’s disease or primary hyperaldosteronism results from excess secretion of aldosterone (a hormone that regulates salt and water balance) from 1 or both of the adrenal glands (located just above the kidneys).
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